Paloxi

PALOXI® scene DESCRIPTION ® Paloxi (palonosetron hydrochloride) is an antiemetic and anti maladynt agent. It is a serotonin subtype 3 (5-HT3) receptor antagonist with a unbendable covering affinity for this receptor. Chemically, palonosetron hydrochloride is: (3aS)-2-[(S)-1-Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1oxo-1Hbenz[de]isoquinoline hydrochloride. The empirical conventionalism is C19H24N2O.HCl, with a molecular weight unit of 332.87. Palonosetron hydrochloride exists as a single isomer and has the following geomorphologic formula: Palonosetron hydrochloride is a white to off -white crystalline powder. It is freely dissoluble in water, soluble in propylene glycol, and meagerly soluble in ethanol and 2 -propanol. ® Paloxi injection is a sterile, clear, colorless, non-pyrogenic, isotonic, buffered radical for intravenous ® administration. Each 5-ml vial of Paloxi injection contains 0.25 mg palonosetron enter as hydrochloride, 207.5 mg mannitol, ede tate disodium dihydrate, trisodium citratedihydrate, citric aci d monohydrate, and water for injection for intravenous administration. The pH of the solution is 4.5 to 5.5.

CLINICAL PHARMACOLOGY weapon of Action Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this receptor and litt le or no affinity for other receptors. Cancer chemotherapy may be associated with a high incidence of malady and vomiting, particularly when certain agents, much(prenominal) as cisplatin, are used. 5-HT3 receptors are located on the mall terminals of the vagus in the periphery and centrally in the chemoreceptor egg on zone of the area postrema. It is th! ought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small catgut and that the released s erotonin then activates 5-HT3 receptors located on vagal afferents to creation father the vomiting reflex. Pharmacodynamics The effect of palonosetron on blood pressure, tenderheartedness rate, and electrocardiogram parameters including QTc...If you want to get a full essay, coiffure it on our website: OrderCustomPaper.com

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